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绝对基质氧化率在老年人中较低,有amnestic轻度认知障碍

Nicholas A Rizzi¹, Mary K Kramer², Theodore M DeConne¹

¹Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.

Physiological reports

|April 14, 2025

概括

在有氧运动期间,患有缓解性轻度认知障碍 (aMCI) 的老年人显示脂肪氧化 (FatOx) 和碳水化合物氧化 (CHOOx) 的峰值降低. 运动期间这种代谢变化可能会影响这个人群的整体体力能力.

科学领域:

运动生理学运动生理学
神经科学是一个神经科学.
代谢健康代谢健康

背景情况:

轻度认知障碍 (MCI) 与改变的休息代谢功能有关.
患有MCI的个体在有氧运动期间的代谢反应尚不清楚.

研究的目的:

为了比较脂肪氧化 (FatOx) 和碳水化合物氧化 (CHOOx) 在分级运动测试 (GXT) 期间的脂肪氧化 (FatOx) 和碳水化合物氧化 (CHOOx) 速率,在患有amnestic轻度认知障碍 (aMCI) 的人群中,与认知无障碍 (CU) 控制人群相比.
调查aMCI和CU集团之间行使能力的潜在差异.

主要方法:

22名aMCI和21个CU的老年人接受了GXT.
使用氧气消耗 (VO2) 和二氧化碳产量 (VCO2) 的测量方法来确定FatOx和CHOOx的比率.
记录了峰值氧气消耗 (VO2峰值) 和疲劳的时间.

主要成果:

在aMCI和CU组之间,休息绝对和相对FatOx和CHOOx率相似.
与CU相比,aMCI组的FatOx和CHOOx的峰值绝对率明显较低.
aMCI组表现出明显较低的疲劳时间和绝对VO2峰值.

结论:

患有aMCI的老年人在有氧运动期间显示脂肪和碳水化合物氧化峰值降低.
这些发现表明aMCI的运动期间代谢灵活性受损.
运动基质氧化减少可能导致aMCI运动能力下降.

关键词:

缓慢的认知障碍缓慢的认知障碍运动就是炼身体.基质氧化过程中的基质氧化.

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