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移植患者中的COVID-19:报告22例病例
Rihab Manaa1, Meriem Ben Salem, Manel Ben Salah
1From the Department of Nephrology, Dialysis and Transplantation, University Hospital of Monastir, Tunisia.
概括
被诊断为COVID-19的移植接受者经历了显著的症状和移植功能障碍. 免疫功能低下的患者面临高死亡率和急性损伤率,最佳治疗方法尚不清楚.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 移植免疫学 移植免疫学
背景情况:
- 新型呼吸道疾病COVID-19在2019年底出现.
- 移植接受者 (KTRs) 代表了一个由于长期免疫抑制而易受伤害的人群.
研究的目的:
- 分析突尼斯移植接受者的COVID-19患者特征,管理和预后.
- 评估SARS-CoV-2感染在这个特定队列中的临床表现和结果.
主要方法:
- 追溯性,描述性和分析性研究.
- 包括2020年3月至2021年12月期间住院的被诊断为COVID-19的KTR.
- 分析患者的人口统计,并发症,症状,实验室发现和治疗策略.
主要成果:
- 包括22名KTR (平均年龄为43.5岁,78.3%为男性).
- 常见的症状包括疲劳,肌痛,厌食症,咳和头痛.
- 81.8%的人经历了移植功能恶化; 27.3%的人患有严重的SARS-CoV-2感染.
- 死亡率为9%,完全康复率为72%.
结论:
- 在KTR中,COVID-19呈现异质的显著风险.
- 免疫功能受损的KTR容易导致高死亡率和急性损伤.
- 在KTR中针对COVID-19的最佳治疗策略需要进一步调查.
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