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Updated: May 13, 2025

Preparation of Nucleosome Core Particles Complexed with DNA Repair Factors for Cryo-Electron Microscopy Structural Determination
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一个平衡行为:提氨基DNA糖酶结合了序列和旋转偏好,以定义核细胞核粒子中的损伤切除

Julia C Ferrara1, Sarah Delaney1

  • 1Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.

Biochemistry
|April 14, 2025
PubMed
概括

胺DNA糖酶 (TDG) 从核细胞核颗粒中切除乌拉,其活性受DNA定位和序列的影响. 由于其表观遗传作用,TDG更喜欢可访问的5'-UpG-3'和5'-UpA-3'位点.

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