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水性聚氨稳定凝涂层具有医疗导管上的滑和抗菌特性

Peipei Zhang¹, Yang Gao¹, Shaohai Li¹

¹Polymeric and Soft Materials Laboratory, School of Chemical Engineering and Advanced Institute of Materials Science, Changchun University of Technology, No. 2055, Yan'an Street, Changchun 130012, P. R. China.

ACS applied materials & interfaces

|April 14, 2025

概括

一种新的水性聚氨 (WPU) 涂层策略增强了医疗导管上的水凝粘附力. 这改善了滑,并提供了强大的抗微生物特性,减少了感染和创伤的风险.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
医疗设备工程医疗设备工程

背景情况:

医疗导管需要滑和抗菌性质,以防止组织创伤和感染等并发症.
现有的水凝涂层往往遭受弱的界面粘附,导致分层和设备故障.

研究的目的:

开发一种强大的水凝涂层用于医疗导管,具有增强的粘附,滑和抗菌能力.
为应对水凝涂层医疗器械界面粘附性较弱的挑战.

主要方法:

一个两步的涂层过程,涉及水性聚氨 (WPU) 初始剂,其次是UV启动的水凝生长.
水凝配方包括四分位氨基基托 (QCS),硫乙烯甲基烯酸盐 (SBMA),N-乙烯酸 (NVP) 和硫酸肝 (ZnSO4·7H2O).
粘附强度,水友性,表面摩擦和抗菌有效性的表征.

主要成果:

为水凝涂层实现了强大的536N/m的界面粘接强度.
由于水化层的形成,证明了出色的水友性 (WCA = 24.6°) 和较低的表面摩擦 (COF = 0.0357).
呈现出显著的抗微生物活性,对抗阴性 (大肠杆菌) 和阳性 (细菌) 细菌.

结论:

由WPU引发的策略有效地在导管上创建了稳定,可调节和功能性的水凝涂层.
这种方法提供了一个有前途的解决方案,通过减少并发症来提高导管的性能和患者安全.
开发的水凝涂层具有强大的粘附性,滑性和广泛的抗菌性质的独特组合.

关键词:

它是一种抗菌药物,具有抗菌作用.水凝涂层是用水凝涂层进行的.接口粘合接口粘合滑方式滑方式在水中传播的聚氨.

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