最佳超大尺寸与新一代的进化 (PRO/PRO+/FX) 自扩展:一个多中心研究
Silvia Mas-Peiro1, Alberto Alperi2, Ander Regueiro3,4
1Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (S.M.-P., A.P., S.M., M.A., J.R.-C.).
Circulation. Cardiovascular interventions
|April 14, 2025
概括
在用Evolut替换跨导管大动脉 (TAVR) 时,较高的门过大,减少了对门泄漏 (PVL). 这项研究发现,增加过大尺寸与较低的PVL发病率相关,而不会增加并发症风险.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 准膜泄漏 (PVLs) 是通过导管的大动脉替换 (TAVR) 后的一个重大并发症.
- 门过大,特别是自扩展门,可能会减少PVL的发生.
- 超大尺寸与较新的Evolut代对PVL的影响尚未得到充分证实.
研究的目的:
- 在现实环境中评估Evolut门超大尺寸对PVL率的影响.
- 评估门超大尺寸和TAVR后PVL发病率之间的关系.
- 为了确定超大尺寸是否会影响其他临床结果.
主要方法:
- 一项多中心,两样性研究包括接受TAVR并使用Evolut PRO/PRO+/FX门的患者.
- 超大小的程度是使用多探测器计算机断层扫描的大动脉环周长度计算的.
- 主要终点是PVL存在 (轻度/中度至重度) 通过心声学;次要终点包括Valve学术研究联盟-3定义的住院结果.
主要成果:
- 分析了762名患者;中位数的超大小是20%.
- 较大的超大尺寸 (>20%) 与较低的PVL发病率有关 (30.2%与40.9%,P=0.002).
- 增加的超大尺寸与减少PVL风险相关 (或0.95每1%的增加,P=0.006),而不会影响死亡率,中风或永久心脏起器率.
结论:
- 更高的Evolut门超大尺寸与TAVR后PVL的频率下降有关.
- 这种关联在没有增加其他并发症的风险 (如永久心脏起器植入) 的情况下是正确的.
- 建议避免Evolut门的低超大小度,特别是在边界情况下.
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