在新发病治疗中,肠道病毒组概况原始沙特儿童患有性结肠炎
Mohammad El Mouzan1, Tor C Savidge2,3, Ahmed Al Sarkhy1
1Department of Pediatrics (Gastroenterology Unit), College of Medicine, King Saud University, Riyadh, Saudi Arabia.
概括
小儿性结肠炎 (UC) 的肠病毒组变化在地理上有所不同. 沙特儿童患有新发性UC的特定菌体特征表明,在基于微生物群的诊断中存在人口偏见.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 肠道微生物组的不平衡与西方人群的性结肠炎 (UC) 有关.
- 人们对肠道病毒组的作用和对UC相关微生物组的地理影响不太了解.
- 这项研究调查了菌体的变化及其与UC的关联.
研究的目的:
- 在新发性UC的儿童中表征肠道菌体变化.
- 识别菌-细菌协会作为潜在的UC生物标志物.
- 探索UC相关病毒组的地理差异.
主要方法:
- 从便和直肠活检中对DNA进行枪支元基因组测序.
- 对20名患有UC的未经治疗的儿童和20名健康对照者的分析.
- 生物信息学和统计分析以评估菌体多样性和细菌协会,使用随机森林进行生物标记物识别.
主要成果:
- 在便样本中,菌体的多样性没有显著改变.
- 在UC患者中,有72种菌体物种发生显著变化.
- 确定了五种物种 (沙门氏菌SEN4,未培养的crAssphage,类似SPbeta的StaphylococcusStreptococcusYMC-2011,SifhoviridaeS) 作为候选生物标志物.
结论:
- 在沙特儿童中观察到一种明显的菌体特征,这些儿童患有新发性UC.
- 这些发现与之前报告的西部UC病例不同.
- 在基于非西方微生物群的诊断和治疗方面,必须考虑人口因素.
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