与急性期帕克斯洛维德使用相关的长期中风和死亡风险降低在轻度至中度的COVID-19中
Cheng-Hsun Chuang1,2,3, Yu-Hsun Wang1,4, Liang-Tsai Yeh5,6,7
1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Journal of medical virology
|April 14, 2025
概括
在急性COVID-19中使用Paxlovid (nirmatrelvir/ritonavir) 显著降低了长期COVID相关中风和死亡的风险. 这种抗病毒治疗提供了对长期脑血管事件和感染后死亡的关键保护.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期COVID,是COVID-19诊断后超过3个月发生的疾病,可能包括脑血管事件,如中风.
- 抗病毒治疗的有效性,如Paxlovid (nirmatrelvir/ritonavir),在减轻长期的COVID-19并发症仍然是一个活跃的调查领域.
研究的目的:
- 为了确定在轻度至中度的COVID-19急性阶段服用Paxlovid是否会降低长期COVID期间缺血性或出血性中风的风险.
- 评估Paxlovid对长期COVID患者全因死亡率的影响.
主要方法:
- 使用TrinetX电子健康记录 (11800万患者) 的回顾性队列研究.
- 患有COVID-19 (2022-2023) 的成年人被分为Paxlovid (5天内诊断) 和非Paxlovid组.
- 倾向性得分匹配 (1:1比) 控制混因素;使用生存曲线和考克斯模型分析中风和死亡率.
主要成果:
- 帕克斯洛维德的使用与长期COVID期间 (>诊断后90天) 缺血性和出血性中风 (HR 0.85;95% CI:0.80-0.89) 和全因死亡率 (HR 0.68;95% CI:0.63-0.73) 的显著降低风险有关.
- 保护作用在包括老年人和患有肥胖等代谢疾病的个体在内的各个子组一致,并且独立于疫苗接种状态.
结论:
- 在急性COVID-19期间使用Paxlovid显著降低了长期脑血管事件和死亡率的风险.
- 这些发现强调了Paxlovid在缓解COVID-19相关的长期并发症方面发挥的关键作用,包括神经系统的后果.
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