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识别性关节炎叠加于晶体关节病:细胞计数是答案吗?

Allison M Morgan¹, Sehar Ferati¹, Chloe Fong¹

¹Department of Orthopedic Surgery, New York University Langone Health, 1056 5th Avenue, New York, NY, 10028, USA.

Journal of clinical orthopaedics and trauma

|April 14, 2025

概括

败血性关节炎 (SA) 可能难以区分于晶体性关节炎 (CA). 一个突白细胞 (WBC) 数量为5万个细胞/mm3可以帮助诊断SA在CA的患者.

科学领域:

整形外科整形外科整形外科
类风湿病学类风湿病学
传染性疾病传染性疾病

背景情况:

败血性关节炎 (SA) 是一种严重的骨科疾病,患病率和死亡率很高.
区分SA和结晶性关节炎 (CA) 具有挑战性,因为它们可能同时发生.
在CA的背景下,确定SA的可靠诊断标记是必不可少的.

研究的目的:

为了确定SA在CA患者中SA的患病率.
识别和验证实验室标记物,以诊断在CA的存在下SA.
为这些标记物定义最佳的诊断值.

主要方法:

对成年患者的回顾性审查,在膝关节突液中含有单酸盐 (MSU) 或酸盐 (CPP).
在2012年1月至2023年3月期间,对225个膝盖愿望进行了分析.
统计分析包括千平方测试,ROC曲线和Youden指数用于值的确定.

主要成果:

确定了12例 (5.3%) 叠加的SA,其中11例通过培养得到确认.
免疫抑制与更高的SA发病率有关 (41.7%与14.6%相比).
在SA病例中,状白细胞计数显著增加 (135,796 vs 22,510). 最佳值为5万个细胞/毫米3,显示91.7%的灵敏度和90.1%的特异性.

结论:

同胞白细胞 (WBC) 计数是CA.的设置中SA的有价值的诊断标志物.
对状白细胞的最佳诊断值是5万个细胞/mm3.3.
这种标志物有助于区分SA和CA,改善患者管理.

关键词:

结晶性关节病是指结晶性关节病.这是一种痛风,痛风.伪风风病是一种伪风病.败血性关节炎是什么意思

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