系统性炎症反应指数与美国成年人心脏代谢多病症的关联:基于人口的研究
Jing Li1, Songfeng Zhao2, Xiaowen Zhang1
1Department of Neurointervention at The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
系统性炎症反应指数 (SIRI) 的升高与心脏代谢性疾病 (CMD) 和多病症 (CMM) 的更高率有关. 这种新型生物标志物显示出对这些疾病的非侵入性评估的潜力.
科学领域:
- 心血管医学 心血管医学
- 代谢健康 代谢健康
- 炎症研究 炎症研究
背景情况:
- 慢性炎症是心脏代谢疾病 (CMD) 的关键因素.
- 系统性炎症反应指数 (SIRI) 是一种新的炎症生物标志物.
- 了解SIRI与心脏代谢多病症 (CMM) 的关联至关重要.
研究的目的:
- 调查SIRI与不同心脏代谢多病症 (CMM) 状态之间的关系.
- 评估SIRI对CMD和CMM的诊断价值.
主要方法:
- 使用国家健康和营养检查调查数据 (1999-2018) 进行横截面研究.
- SIRI计算为中性粒细胞数 × 淋巴细胞数/单细胞数.
- 用于分析的加权多变量逻辑回归和ROC曲线.
主要成果:
- 总共有43,345名参与者被分析.
- 升高的SIRI独立地与糖尿病,心脏病,中风,中风,中风和中风的几率增加有关.
- 与其他炎症比率相比,SIRI显示了CMD和CMM的优越诊断能力.
结论:
- 升高的SIRI与CMD和CMM的患病率有关.
- SIRI可以作为一种潜在的非侵入性生物标志物,用于识别有CMD和CMM风险的个体.
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