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怀孕期间贫血与母亲重症监护室入院之间的关联:系统性审查和元分析

Tejaswini B Darukaradhya¹, Asmitha Bhateja², Sujata Siwatch³

¹Division of Public Health, Department of Allied Health Sciences, Faculty of Life and Allied Health Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka 560054 India.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

|April 14, 2025

概括

怀孕期间的贫血可能会增加母亲进入重症监护室 (ICU) 的风险. 然而,由于研究的显著变化和潜在的出版偏差,研究结果需要谨慎解释.

科学领域:

产科和妇科产科和妇科
关键护理医学关键护理医学
血液学血液学血液学

背景情况:

怀孕期间的贫血是一种普遍的疾病,可能对母亲和胎儿产生不良后果.
关于怀孕期间贫血与母亲重症监护室 (ICU) 住院之间的关联现有的研究是不一致的.
本次元分析解决了对这种关系进行全面评估的需要.

研究的目的:

为了确定贫血在孕妇的整体影响在ICU入院的风险.
综合观察性研究的证据,比较贫血和非贫血孕妇之间的ICU入院率.

主要方法:

在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science) 中进行了系统的文献搜索.
包括观察性研究,比较贫血和非贫血孕妇的ICU入院风险.
使用随机效应模型将几率比率 (ORs) 结合起来,使用预测间隔 (PI) 和I2统计数据评估异质性. 进行了敏感性分析和出版偏差评估.

主要成果:

包括8项研究,包括超过2100万参与者.
七项研究的初步元分析得出了一个1.32 (95% CI 0.62-2.81) 的综合OR,用于贫血孕妇的ICU入院,具有非常高的异质性 (I2 = 100%).
排除一个有影响力的研究导致了1.16 (95% CI 1.13-1.20) 的显著聚合OR,但检测到出版偏差 (LFK指数 = -3.64).

结论:

怀孕期间的贫血可能与母亲入住ICU的风险增加有关.
显著的异质性和潜在的出版偏见需要对研究结果进行谨慎的解释.
需要进一步进行高质量的研究,以澄清怀孕期间贫血与ICU入院之间的明确联系.

关键词:

在重症监护病房的重症监护病房.孕产妇的贫血症母亲的贫血症进行元分析分析.系统性审查系统性审查

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