唾液细菌减少酸盐,促进葡萄糖代谢和生活方式
Evangelia Morou-Bermúdez1, Kai Guo1, Jairelisse Morales Morales1
1School of Dental Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA.
Journal of oral microbiology
|April 14, 2025
概括
口腔细菌减少酸盐与更好的葡萄糖代谢和胰岛素敏感性有关. 像吸烟和刷牙习惯这样的生活方式因素会影响这个过程,为糖尿病预防提供了潜力.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 口腔健康 口腔健康
背景情况:
- 口腔细菌具有酸盐减少酶 (NR),可以将酸盐转化为酸盐.
- 亚酸盐可以通过溶解性酸盐降解 (DNRA) 或氧化 (NO) 进一步代谢为,影响心脏代谢健康.
研究的目的:
- 研究唾液细菌的酸盐降低能力,葡萄糖代谢标记物和生活方式因素之间的关系.
- 了解口腔环境调制如何影响DNRA和NR的表达.
主要方法:
- 来自圣胡安超重成人纵向研究 (SOALS) 的144名参与者的横截面研究.
- 在有氧和CO2丰富的条件下测量了唾液DNRA和NR活动.
- 数据包括葡萄糖代谢标志物和生活方式因素.
主要成果:
- DNRA活性与胰岛素耐药性 (HOMA-IR),禁食血糖和2小时血糖呈反向关联.
- 吸烟状态,刷牙频率和身体活动调节了DNRA和NR活动.
- NR活性受到BMI,糖的存在和唾液中酸盐水平的影响.
结论:
- 唾液中酸盐的减少与胰岛素抵抗相反相关.
- 生活方式因素显著调节口腔酸盐降低细菌的活动.
- 研究结果表明,对于糖尿病进展的非侵入性监测和预防策略有潜力.
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