重温淋巴结指南:对于老年胃癌患者,有限的淋巴结检查可能足够
Xiaojie Zhang1, Tao Fu1, Guochao Zhang1
1Gastrointestinal Surgery Department, China-Japan Friendship Hospital, Beijing, China.
Translational cancer research
|April 14, 2025
概括
对于接受全胃切除术的老年胃癌患者来说,有限数量的检查淋巴结 (ELN) 可能是足够的. 在这组患者中,有限和推的ELN数量之间,生存结果没有显著差异.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 手术瘤学手术瘤学
背景情况:
- 对于老年胃癌 (GC) 患者的长期结果,有限的检查淋巴结 (ELN) 计数与推计数的充分性是有争议的.
- 这项研究解决了老年GC患者淋巴结检查标准的争议.
研究的目的:
- 为了比较具有有限ELN计数的老年GC患者和具有推ELN计数的老年GC患者的长期存活率.
- 评估ELN数量对老年GC患者癌症特异性生存期 (CSS) 和整体生存期 (OS) 的影响.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库中对老年GC患者 (75岁以上) 的回顾性分析.
- 在有限的ELN组 (ELN <15) 和推的ELN组 (ELN ≥15) 之间比较CSS和OS.
主要成果:
- 在有限的 (n=793) 和推的 (n=728) ELN组之间,CSS没有统计学上显著的差异 (P=0.31).
- 在接受全胃切除术 (P=0.16) 的患者中,总生存率 (OS) 在各组之间相似 (P=0.16).
- 然而,在接受近端或远端胃切除术的患者中,在有限的ELN组中,OS显著较短 (P<0.001).
结论:
- 对于经过全胃切除术的老年GC患者来说,检查的淋巴结数量有限可能足够.
- 需要进一步的前性研究,采用更大的样本大小来验证这些发现,并完善淋巴结检查指南.
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