相关实验视频
Updated: Jul 6, 2026

05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
10.0K
胃食道逆流性疾病和高血压之间的关联:系统性审查和元分析
Ganesh Bushi1,2, Abhay M Gaidhane3, Nasir Vadia4
1Chitkara Centre for Research and Development Chitkara University Baddi India.
概括
胃食道逆流性疾病 (GERD) 可能会增加患高血压 (HTN) 的风险. 这次审查发现,GERD患者患HTN的可能性更高,这表明需要进一步调查的潜在联系.
科学领域:
- 胃肠病学和心脏病学
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- 胃食道逆流性疾病 (GERD) 和高血压 (HTN) 是具有重大公共健康影响的普遍疾病.
- 关于GERD和HTN之间关联的现有研究是不一致的.
- 这项研究系统地审查和元分析观察数据,以澄清GERD-HTN关系.
研究的目的:
- 系统地审查和元分析观察性研究.
- 为了确定在患有GERD的患者中HTN的综合流行率.
- 评估在患有GERD的个体中发展HTN的风险.
主要方法:
- 在PubMed,Web of Science和Embase的系统文献搜索到2024年12月.
- 包括评估GERD和HTN流行和关联的观察性研究.
- 随机效应元分析以计算聚合的流行率和风险估计,使用I2统计评估异质性.
主要成果:
- 分析了12项包括71至12960名参与者的研究.
- 在GERD患者中HTN的综合患病率为16.80% (95% CI:6.28%-31.02%) 具有很高的异质性 (I2=99%).
- 对HTN的综合风险比为1.381 (95% CI:0.992-1.922),表明潜在的风险增加,具有显著的异质性 (I2=76%).
结论:
- 胃食道逆流性疾病 (GERD) 被确定为高血压 (HTN) 的潜在危险因素.
- 患有GERD的患者患高血压的可能性增加.
- 需要进一步的研究来阐明影响这种关联的潜在机制和混因素.
相关概念视频
Disorders of the Autonomic Nervous System
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...

