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Updated: May 13, 2025

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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
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在肥胖儿科人口中,高尿血,身体成分和并发症之间的关联
João Vasco1, Mónica Tavares2, Helena Ferreira Mansilha2
1Pediatric Department, Hospital do Divino Espírito Santo, Ponta Delgada, Azores, Portugal.
Journal of nutrition and metabolism
|April 14, 2025
概括
肥胖儿童的血清尿酸 (SUA) 与人体组成和伴随性疾病 (如胰岛素抵抗和脂肪肝疾病) 相相关. 腰与身高的比率和体脂百分比比较好地预测并发症,而不是单独的BMI.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 儿童肥胖是一个具有长期后果的全球健康危机.
- 血清尿酸 (SUA) 的升高与成年人的并发症有关,但其在儿童中的作用不太清楚.
- 虽然体重指数 (BMI) 与SUA有关,但其他营养评估及其与儿童肥胖并发症的联系需要进一步调查.
研究的目的:
- 调查高尿血,身体组成和儿童肥胖相关并发症之间的关系.
- 为了比较BMI,腰与身高比率 (WHtR) 和身体脂肪质量 (BFM) 百分比在评估这些关系中的有效性.
主要方法:
- 对505名肥胖儿童 (5-18岁) 的回顾性分析.
- 评估BMI z-score,WHtR和BFM百分比 (通过生物阻抗).
- 评估SUA水平和针对目标器官损伤的血液标志物,包括HOMA-IR,ALT和脂质资料.
主要成果:
- 所有营养评估方法 (BMI,WHtR,BFM) 都显示出显著的相关性 (p < 0.001).
- WHtR与伴随疾病的相关性比BMI z-score更强.
- 在回归分析中,SUA水平与HOMA-IR,ALT和脂质资料有显著的相关性 (p < 0.001),并与BFM百分比和WHtR相关.
- 患有肝硬化症的儿童在身体组成,SUA和并发症标志物上表现出显著差异.
结论:
- 营养评估方法有很强的相关性,WHtR和BFM百分比比BMI更能表明肥胖并发症.
- 血清尿酸是肥胖儿童胰岛素抵抗,炎症和代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的潜在生物标志物.
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