巨细胞膜功能化的纳米治疗药物用于瘤向治疗
Mubassir Khan1, Razi Ullah2, Guixue Wang2
1Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P.R. China.
Theranostics
|April 14, 2025
概括
巨细胞膜封装的纳米疗法通过利用巨细胞的特性来提高药物输送和免疫反应,提供向癌症治疗. 本综述探讨了它们的制备,免疫疗法应用以及未来的临床潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 传统的癌症疗法在特异性和有效性方面存在局限性.
- 巨细胞膜具有固有的瘤向和免疫调节能力.
- 使用细胞膜的生物仿真方法正在出现用于药物输送.
研究的目的:
- 审查巨细胞膜封装纳米疗法治疗癌症的最新进展.
- 讨论这些纳米治疗药物的制备,表征和免疫治疗应用.
- 突出临床翻译的未来前景和挑战.
主要方法:
- 在巨细胞膜封装的纳米疗法制剂的制备和表征.
- 探索免疫疗法策略,包括巨细胞两极分化和T细胞透.
- 关于巨细胞膜修饰和诱导免疫细胞死亡的讨论.
主要成果:
- 巨细胞膜赋予独特的特性:瘤向,免疫逃避,并在瘤微环境中释放有效载荷.
- 这些纳米治疗药物在增强癌症免疫疗法方面表现出潜力.
- 该综述综合了当前关于其制备和应用的研究.
结论:
- 巨细胞膜封装的纳米治疗药物代表了针对性癌症治疗的有希望的战略.
- 需要进一步的研究来解决局限性问题并促进临床转型.
- 这种仿生方法有可能开发先进的化疗.
更多相关视频
09:36Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
Published on: February 5, 2019
8.6K
07:59A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
8.8K
相关概念视频
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:27Tumor Immunotherapy
404
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
404
02:17The Tumor Microenvironment
6.4K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.4K