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底侧杏仁体 - 前环状皮质回路有助于后神经疼痛 - 焦虑并发症

Xiaofeng Jiang^1,2, Yi Yan^1,3, Ziming Chen^1,3

¹Jiangxi Key Laboratory of Trauma, Burn and Pain Medicine, Nanchang, China.

|April 14, 2025

概括

随着焦虑的后神经痛 (PHN) 涉及杏仁体体积的减少和底侧杏仁体 (BLA) - 前带皮层 (ACC) 电路活动的改变. 针对BLA-ACC通路提供了管理PHN疼痛和焦虑的潜力.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
精神病学是一个精神病学.

背景情况:

术后性神经疼痛 (PHN) 的特点是慢性疼痛和情绪功能障碍,其潜在机制尚不清楚.
伴随性焦虑加剧PHN的影响,需要对其神经生物学基础进行研究.

研究的目的:

为了调查PHN和伴随性焦虑症患者的神经成像差异.
使用临床前模型阐明基底侧杏仁体 (BLA) - 前环状皮质 (ACC) 电路在PHN相关的焦虑类行为中的作用.

主要方法:

在PHN焦虑患者和健康对照中比较结构和功能MRI.
开发一种由树脂胺毒素 (RTX) 诱导的PHN类似焦虑的小鼠模型.
多模式分析包括行为测试,电生理学,病毒追踪,光纤摄影学,光遗传学和化学遗传学.

主要成果:

患有PHN焦虑症的患者表现出杏仁体体积减少和BLA和ACC之间的功能连接性降低.
在RTX模型中显示了类似焦虑的行为和机械/热过敏.
观察到BLA谷氨基基 (BLA^Glu) 神经元的增强激活,它们的激活加剧了疼痛和焦虑,而抑制缓解了这些症状.
调节BLA^Glu-ACC通路直接影响疼痛和焦虑行为.

结论:

BLA-ACC电路在PHN焦虑并发症的中心机制中发挥着关键作用.
这些发现为开发焦虑PHN的向治疗提供了理论基础.

关键词:

前带带皮层前带带皮层基本侧面的杏仁体神经电路中的神经回路.术后性神经疼痛术后性神经疼痛功能磁力共振成像 (fMRI) 是一种

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