通过促进Sirt7介导的Keap1脱乙和Keap1-Nrf2解离,GLSP减轻了血管衰老
Yanfei Cheng1, Guobin Zheng2, Heming Huang3
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Theranostics
|April 14, 2025
概括
甘白斑子粉 (GLSP) 通过激活Sirt7-Nrf2通路来延缓血管衰老,动脉样硬化和化. 这种天然化合物为抗击与年龄相关的血管疾病提供了新的策略.
科学领域:
- 老年学和心血管科学研究
- 药理学和天然产品研究 药理学和天然产品研究
- 分子生物学和衰老机制
背景情况:
- 血管衰老是整体衰老的关键指标,也是动脉样硬化和血管化的主要驱动因素.
- 目前针对血管衰老的药理干预措施有限,这凸显了对新型治疗策略的需求.
- 了解参与血管衰老的分子通路对于开发有效治疗非常重要.
研究的目的:
- 为了研究Ganoderma lucidum子粉 (GLSP) 对血管系统的抗衰老作用.
- 阐明GLSP减轻血管衰老,动脉样硬化和化的分子标和机制.
- 评估GLSP对与年龄相关的血管疾病的治疗潜力.
主要方法:
- 在老年C57BL/6J小鼠中评估GLSP的抗血管衰老作用.
- 通过转录组测序确定GLSP目标,并评估其在相关小鼠模型中对动脉样硬化和血管化的保护作用.
- 研究GLSP三烯对血管光滑肌细胞 (VSMC) 的 in vitro 影响,重点关注衰老和化.
主要成果:
- 通过调节细胞周期,衰老相关分泌表型 (SASP),DNA损伤,氧化应激,线粒体功能和新陈代谢,GLSP显示了抗血管衰老的特性.
- 在体内研究表明GLSP改善了与血管衰老相关的动脉样硬化和化.
- 从机制上来说,GLSP上调了Sirt7,Sirt7与Keap1相互作用,通过脱乙和解离促进了Nrf2的激活,从而缓解了VSMC老化和化.
结论:
- GLSP有效地减轻了血管衰老,动脉样硬化和血管化.
- 主要机制涉及通过激活Sirt7-Nrf2信号轴调解的抗氧化作用.
- GLSP代表了一种有前途的自然治疗策略,可以延缓血管衰老和相关疾病.
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