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Updated: Jul 20, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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可注射的基于细胞囊泡的骨粉用于通过恢复免疫恒常度来修复炎症性骨缺陷

Yu-Yue Zhao1, Qian-Fang Meng2, Hao Cui1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

Theranostics
|April 14, 2025
PubMed
概括

这项研究引入了一种可注射的骨移植材料,使用骨髓衍生抑制细胞 (MDSC) 膜囊泡来恢复免疫平衡. 该材料通过减少炎症和平衡骨缺陷中的细胞活性,有效地促进骨再生.

关键词:
细胞膜囊泡中的细胞膜囊泡.在MDSCs中.骨面粉骨面粉骨面粉骨面粉骨面粉骨面粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨粉骨骨的修复 骨的修复免疫系统的恒常性.

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...