在经过治疗的PLWH中估计感染SARS-COV2感染的风险:一个病例控制研究
Pierluigi Francesco Salvo1, Valentina Iannone1, Francesca Lombardi2
1Università Cattolica del Sacro Cuore, Roma Italia- Dipartimento di Sicurezza e Bioetica sezione Malattie Infettive, 00168 Roma, Italy.
Global epidemiology
|April 14, 2025
概括
艾滋病毒感染者 (PLWH) 面临更高病毒载荷的SARS-CoV-2感染风险增加. 接种疫苗和监测HIVRNA对于管理PLWH中的COVID-19至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 人类免疫缺陷病毒 (HIV) 和艾滋病毒感染者 (PLWH) 感染SARS-CoV-2的风险之间的关系尚不清楚.
- 了解PLWH治疗中SARS-CoV-2获取的特定风险因素对于有针对性的干预措施至关重要.
研究的目的:
- 确定在经过治疗的PLWH中获得SARS-CoV-2的独立风险因素.
- 阐明在接受抗逆转录病毒治疗的PLWH中与SARS-CoV-2感染相关的潜在风险因素.
主要方法:
- 一项涉及220名来自意大利传染病诊所的PLWH (72例,148例对照) 的病例控制研究.
- 参与者使用问卷进行了采访,以确定2020年3月至2022年6月期间的SARS-CoV-2感染状况.
- 对照组与病例相匹配,根据潜在暴露时间与SARS-CoV-2相匹配.
主要成果:
- 最近几年 (2022年与2020年相比) 观察到SARS-CoV-2感染的几率增加,并且在PLWH中,HIV RNA>50副本/毫升的PLWH.
- 接收超过三剂疫苗时,感染几率显著降低.
- 没有参与者患有严重的COVID-19疾病;只有一人需要住院治疗.
结论:
- 随着时间的推移,PLWH中SARS-CoV-2感染风险增加,可能是由于不断发展的公共卫生措施和病毒变异.
- 可检测的HIV病毒载量与感染SARS-CoV-2的更高风险有关,强调HIVRNA监测的重要性.
- 接种疫苗显著降低了这种PLWH队列中SARS-CoV-2感染的风险.
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