显著的抗瘤效应和严重的多种免疫相关的不良事件在恶性多层甲状腺瘤:两个病例报告
Koharu Harada1,2, Hidehiro Irie1, Akifumi Mitsuishi1
1Division of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Case reports in oncological medicine
|April 14, 2025
概括
两名患有恶性多层甲骨瘤的患者经历了严重的免疫相关不良事件 (irAEs),但取得了显著的抗瘤反应. 这表明,在MPM中,irAE强度和治疗疗效之间存在相关性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胸部外科手术 胸部外科手术
背景情况:
- 免疫检查点抑制剂 (ICI) 用于治疗各种癌症.
- 与免疫相关的不良事件 (irAEs) 是ICI的常见副作用.
- 在一些癌症中观察到irAEs和抗瘤效应之间的相关性,但对恶性多层层层瘤 (MPM) 的数据有限.
研究的目的:
- 报告两例恶性多叶膜间皮瘤 (MPM) 用ICI治疗的病例.
- 调查严重的IRE与MPM中的抗瘤反应之间的关系.
主要方法:
- 两名患有MPM的患者的病例报告.
- 治疗涉及ICI,导致IRAE.
- 由于irAEs,患者接受了类固醇管理和治疗中断.
主要成果:
- 两位患者都经历了严重的,多次的IRE.
- 尽管有IRE和治疗修改,但这两名患者都获得了完全响应 (CR) 或接近CR的部分响应.
- 在这些情况下,irrAEs的强度大于通常观察到的.
结论:
- 这些发现表明,在MPM中,irAEs的强度和抗瘤作用之间存在强烈的相关性.
- 在接受ICI的MPM患者中,严重的irAEs可能与有利的治疗结果有关.
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