血清Zn和Ca与假阳性非侵入性产前检测结果相关
Gaigai Wang1, Yanqiu Zhang2, Tiantian Wu1
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
American journal of translational research
|April 14, 2025
概括
孕产妇血清中 (Zn) 和 (Ca) 含量与假阳性非侵入性产前检测 (NIPT) 结果有非线性关联,可能与胎盘化有关. 有针对性的补充可以提高NIPT的准确性.
科学领域:
- 生殖生物学 生殖生物学
- 孕产妇和胎儿的医学
- 营养生物化学 营养生物化学
背景情况:
- 在非侵入性产前检测 (NIPT) 中由于胎盘嵌合体的错误阳性结果尚未完全理解.
- 母体血清中必需的矿物质,如 (Zn) 和 (Ca) 对NIPT准确性的影响尚不清楚.
研究的目的:
- 调查母体血清矿物质度与虚假阳性NIPT结果之间的关联.
- 探索血清Zn和Ca在胎盘嵌合体和NIPT结果中的潜在作用.
主要方法:
- 对16,270名孕妇进行了回顾性分析,测定了怀孕14周的血清矿物质含量.
- 在怀孕12至22周之间进行了NIPT,并进行了羊水胆型定型以获得积极的结果.
- 二元物流回归和受限立方线 (RCS) 分析评估了矿物质与虚假阳性NIPT的关联.
主要成果:
- 在假阳性NIPT组中观察到血清矿物质配置的改变 (Na,K,Zn增加;Ca,P,Fe减少).
- 在血清中Zn和Ca水平和NIPT虚假阳性率之间发现了非线性关系.
- 在NIPT虚假阳性,限制性胎盘嵌合体和母体血清Zn/Ca水平之间发现了显著的相关性.
结论:
- 孕产妇血清中Zn和Ca水平与NIPT错误阳性呈现非线性关系,与限制性胎盘嵌合症有关.
- 适度的Zn和Ca补充可以告知营养管理,以提高怀孕测试准确度.
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