在慢性病患者服用达帕格利弗洛辛时,身体组成和手握强度的变化
Takahiro Yajima1, Kaoru Noda2, Kumiko Yajima2
1Department of Nephrology, Matsunami General Hospital, Gifu, Japan.
Clinical kidney journal
|April 14, 2025
概括
在慢性病患者中,达帕格利弗洛辛治疗显示骨肌指数和体液比率下降,但保持了手握强度. 麻症的患病率保持稳定,这表明短期的安全性,但需要长期的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 达帕格利弗洛辛 (Dapagliflozin) 已被认为可以改善脏结果.
- 关于在慢性病 (CKD) 患者中使用达帕格利弗洛辛的安全问题仍然存在.
- 这项研究调查了达帕格利弗洛辛对CKD患者的身体组成和肌肉健康的影响.
研究的目的:
- 评估达帕格利弗洛辛对人体构成的影响,特别是骨肌肉指数和体液.
- 评估达帕格利弗洛辛对手握强度的影响以及CKD患者肉症的患病率.
- 确定Dapagliflozin关于CKD患者肌肉健康的短期安全性.
主要方法:
- 一项前性观察性研究,涉及55名CKD患者 (27名2型糖尿病患者) 用达帕格利弗洛辛10毫克/天治疗24周.
- 测量包括手握强度,骨肌肉指数 (通过生物阻抗分析) 和细胞外水与体内总水比在基线,12周和24周.
- 根据既定的标准,萨科佩尼亚是由手握强度降低和/或骨肌肉指数低来定义的.
主要成果:
- 骨肌指数从基线显著下降到24周 (P < 0.0001).
- 细胞外水与全体水的比率在第24周显著下降 (P = 0.002).
- 手握强度保持不变,在整个24周的治疗期间,肉症的患病率稳定 (P = 0.45).
结论:
- 在CKD患者中,短期服用达帕格利弗洛辛导致骨肌指数和体液比率下降,但没有影响手握强度或肉类的患病率.
- 这些发现表明,达帕格利弗洛辛在慢性病患者中短期内可能对瘤无害.
- 需要进行进一步的长期研究,以充分确定达帕格利弗洛辛在该患者群体中的安全性.
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