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在 postherpetic 神经疼痛患者的并发性抑郁症状时的叶功能障碍

Ying Wu^1,2, Chao Wang³, Wei Qian³

¹Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Brain communications

|April 14, 2025

概括

大脑成像显示,叶 (TL) 功能障碍与后神经疼痛 (PHN) 患者的抑郁症有关. 这种TL-IFG连接影响了情感福祉,为疼痛抑郁症并发症提供了潜在的治疗点.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

抑郁症经常与后神经疼痛 (PHN) 一起发生,这种疾病的神经基础不明.
确定连接疼痛和抑郁症的大脑机制对于有效的治疗策略至关重要.

研究的目的:

研究 postherpetic 神经疼痛患者疼痛和抑郁症并发症的基础的神经机制.
使用休息状态功能性MRI识别与疼痛抑郁并发症相关的特征性脑信号.

主要方法:

观察性研究涉及17名抑郁PHN患者,19名非抑郁PHN患者和34名健康对照 (HC).
休息状态功能性MRI扫描用于分析低频波动 (fALFF) 和区域同质性 (ReHo) 的分数幅度.
进行了Voxel-wise功能连接性分析,并与临床变量相关联.

主要成果:

在这三个组中,在右叶 (TL) 中发现了fALFF值的显著差异.
观察到TL和下额 (IFG) 之间的异常功能连接.
在患有抑郁症的PHN患者中,TL-IFG连接性与积极的情绪和生活质量得分正相关.

结论:

叶功能障碍是PHN群体疼痛抑郁并发症的关键特征.
已识别的TL-IFG途径可能是打破疼痛和抑郁的循环的治疗目标.
研究结果提供了关于伴随性疼痛和抑郁症的神经生物学基础的见解.

关键词:

法尔夫夫夫 (法尔夫夫夫) 的意思功能连接性的功能连接性疼痛-抑郁症并发症术后性神经疼痛术后性神经痛叶的叶叶的叶

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