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Quantitative Autonomic Testing
Published on: July 19, 2011
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神经病患对成年人血糖水平的超运动功能的评估
Qianzhu Wang1,2, Zheng Yang1, Subei Zhao1
1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
概括
随着血糖水平的上升,平侧运动功能会下降. 以前被诊断为糖尿病是运动功能障碍的关键风险因素,影响汗腺活动.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 皮肤病学 皮肤病学
背景情况:
- 通过Neuropad评估的足部运动功能是自主神经病变的敏感指标.
- 代谢指标,包括葡萄糖和HbA1c,与各种神经病变有关.
- 了解这些关系对于早期发现和管理糖尿病并发症至关重要.
研究的目的:
- 评估代谢指标对足部运动功能的影响.
- 使用Neuropad探索代谢,非代谢指标和运动功能之间的关联.
- 在一般体检队列中识别运动功能障碍的预测因子.
主要方法:
- 一项对481名参与者的横截面研究,使用Neuropad进行定性和定量运动功能分析.
- 定量分析使用了10分钟的斜率 (Slope[1-10]) 作为测量运动功能的方法.
- 参与者根据FPG和HbA1c水平被分为正常血糖,糖尿病前期,新诊断的糖尿病和以前诊断的糖尿病组.
主要成果:
- 与正常血糖相比,先前被诊断为糖尿病的患者表现出明显较低的运动功能 (较低的斜率,较高的不完全变色).
- 增加的禁食血葡萄糖 (FPG) 和血红蛋白A1c (HbA1c) 水平与10分钟斜率的逐渐下降相关.
- 以前被诊断为糖尿病是降低运动功能的独立预测因素,增加了不完全变色的风险.
结论:
- 随着血糖水平的上升,脚侧运动功能逐渐下降.
- 以前被诊断为糖尿病是运动功能障碍的独立风险因素.
- 年龄,BMI,ALB,eGFR和酒精消费也显示出与运动功能的显著关联.
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