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揭示Lawsonia inermis L.的潜力:它的抗氧化,抗微生物和抗癌潜力
Nantikan Joyroy1, Lukana Ngiwsara2, Siriporn Wannachat3
1Department of Science and Bioinnovation, Faculty of Liberal Arts and Sciences, Kasetsart University, Nakhon Pathom, Thailand.
PeerJ
|April 14, 2025
概括
(Lawsonia inermis) 提取物,特别是来自极性溶剂的提取物,显示出强大的抗氧化,抗菌和抗癌活性. 这些发现突出了花.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
背景情况:
- 劳森亚无力L. (汉娜) 是一个传统的印度药用植物.
- 以其抗和抗真菌特性而闻名.
- 关于泰国河品种的植物化学成分和生物活性的数据有限.
研究的目的:
- 评估来自泰国的Lawsonia inermis L.提取物的植物化学成分.
- 研究这些提取物的抗氧化,抗菌,抗真菌和细胞毒性质.
主要方法:
- 叶子提取物使用乙醇,甲醇,,和水来制备.
- 用Folin-Ciocalteu和化试验确定和黄含量.
- 生物活性通过抗氧化剂 (DPPH,ABTS,FRAP),抗菌,抗真菌,细胞毒性 (MTT试验) 和抗迁移试验进行评估.
主要成果:
- 乙醇 (HenE) 和甲醇 (HenM) 提取物显示了高的和黄酸盐含量.
- 通过HPLC识别的化合物包括酸,甲素,酸,阿皮格特林,劳森和奎尔塞丁.
- 在HenE和HenM提取物中观察到强烈的抗氧化活性.
- 具有显著的抗菌活性,可以对抗Bacillus cereus和Staphylococcus aureus.
- 对Penicillium sp.具有强大的抗真菌活性 在 HenE 和 HenM. 中观察到.
- 对于大多数提取物,除了 (HenH) 之外,已注意到对各种癌症细胞系 (MDA-MB-231,SW480,A549,A549RT-eto) 的细胞毒性作用.
- HenE和HenM对SW480细胞具有强烈的细胞毒性,其IC50值分别为57.33±5.56μg/ml和65.00±7.07μg/ml.
- (HenC),水 (HenW) 和 (HenH) 提取物抑制了A549细胞迁移.
结论:
- 劳森亚惰性提取物,特别是来自极性溶剂 (HenE,HenM) 的提取物,具有显著的抗氧化,抗菌和抗癌特性.
- 这些发现支持泰国提取物在医药和工业应用中的潜力.
- 建议进行进一步的研究,以探索这些提取物的全部应用潜力.
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