在双极性障碍的euthymic阶段探索残留情绪症状和自我报告的副作用之间的关联:一个横截面网络分析
Nathan Vidal1,2, Eric Brunet-Gouet1,2, Solène Frileux1,2
1Fondation FondaMental, Créteil, France.
Depression and anxiety
|April 14, 2025
概括
双相情绪障碍 (BD) 的残留情绪症状与药物副作用有关. 监测高情绪和能量可以减少副作用和情绪障碍在euthymic阶段.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 双极性障碍 (BD) 标志着情绪波动,这可能会加剧药物的副作用.
- 在euthymic阶段的残留情绪症状是常见的,可以影响生活质量.
研究的目的:
- 为了调查残留情绪症状和BD患者在euthymic阶段自我报告的副作用之间的关联.
- 识别关键的情绪症状和相互关联的副作用.
主要方法:
- 网络分析被用来检查蒙哥马利-阿斯伯格抑郁症评分表 (MADRS),年轻狂热评分表 (YMRS) 和患者评分副作用清单 (PRISE-M) 的52个项目之间的关联.
- 从880名被诊断患有BD的男性和1369名被诊断患有BD的女性收集数据.
- 网络集群和影响情绪和副作用的中心节点在男性和女性中分别被确定.
主要成果:
- 在残留情绪症状和自我报告的副作用之间发现了积极的关联.
- 女性的情绪升高 (YMRS) 和男性的能量增加 (YMRS) 成为中心节点,影响其他情绪症状和副作用.
- 确定了三个不同的集群:一个"情绪集群" (包括情绪和一些副作用项目),一个非性副作用集群和一个性副作用集群. 心和兴奋充当了情绪和副作用之间的桥梁.
结论:
- 临床医生应监测BD的euthymic阶段的情绪升高和能量增加,以减轻残留的情绪症状和副作用.
- 像能量损失,睡眠困难和不安等症状可能代表情绪症状,而不是药物的副作用.
- 心和兴奋可以调解额外的情绪症状和体质投诉的发展.
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