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在Wistar老鼠新生儿中的剂量依赖性肝毒性,这是由于早期生活中暴露于的原因

Navneet Kumar¹, Astha Mathur¹, Suresh Kumar Bunker¹

¹Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.

Journal of biochemical and molecular toxicology

|April 14, 2025

概括

在大鼠中,孕期和断奶期间暴露于酸会导致肝损伤和增加氧化应激. 这突显了由于毒性导致的关键发育时期的重大健康风险.

科学领域:

环境毒理学环境毒理学
发育毒理学发展毒理学
重金属毒性重金属的毒性

背景情况:

是一种普遍存在的环境毒素,也是已知的致癌物.
孕期和断奶等关键发育阶段的暴露会带来独特的健康风险.
了解甲酸的毒理影响对于公共卫生至关重要.

研究的目的:

为了研究暴露于甲在怀孕和断奶期间对Wistar老鼠新生儿的影响.
评估肝功能,氧化应激标志物和对的反应中的基因表达.
在早期发育过程中阐明诱导毒性的机制.

主要方法:

在怀孕和断奶期间,Wistar大鼠暴露于不同剂量的酸 (NaAsO2).
测量了肝脏重量,肝功能测试 (ALT,AST,ALP,GT) 和脂质过氧化 (LPx).
分析了肝脏组织的组织病理学检查,抗氧化酶活性 (GST,GR,GPx,SOD,CAT) 和金属氨酸基因表达.

主要成果:

暴露于酸酸盐导致肝脏重量增加和肝脏组织中的大量积累.
组织学揭示了肝损伤,血管拥堵和炎症.
肝酶 (ALT,AST,ALP,GGT) 和LPx水平升高表明肝细胞损伤和氧化应激.
观察到与剂量相关的抗氧化酶活性下降和金属氨酸基因表达的上调.

结论:

在怀孕和断奶期间暴露于酸会导致Wistar大鼠的肝损伤和氧化应激.
在关键发育时期的毒性会损害肝功能和细胞防御机制.
这些发现强调了在生命早期暴露于环境的潜在健康风险.

关键词:

亚是一种.肝毒性肝毒性肝毒性在金属乙中.氧化应激是一种氧化应激.产后的产后的产后在产前产前产前.

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