结合风险:多环境风险评分和青少年精神病症状
Diandra C Bouter1, Susan J Ravensbergen1, Nita G M de Neve-Enthoven1
1Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, 3000 CA, Rotterdam, The Netherlands.
Schizophrenia bulletin
|April 14, 2025
概括
一个新的多环境风险评分 (PERS) 结合了多种青少年风险因素,可以有效预测精神病症状. 较高的PERS分数显著增加了青春晚期发展精神病经历和症状的几率.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 心理病理学研究 心理病理学研究
- 环境流行病学环境流行病学
背景情况:
- 青少年的精神病症状很常见,并预测未来的精神疾病.
- 调查个别风险因素忽略了它们的累积影响.
- 为了弥补这一差距,开发了一种综合测量方法,即多环境风险评分 (PERS).
研究的目的:
- 开发和验证环境风险因素对青少年精神病障碍的综合测量方法.
- 评估多环境风险评分 (PERS) 与精神病经历和症状之间的关联.
主要方法:
- 一组801名处于危险状态的青少年 (年龄15岁) 被评估了14个二元化风险因素.
- PERS是使用从元分析中获得的日志赔率来计算的.
- 精神病经历和症状在18岁时被评估.
主要成果:
- PERS与自我报告的精神病体验 (PE) 和临床医生评估的精神病症状 (PS) 显著相关.
- 3-4和>4的PERS对应于精神病症状的几率分别增加了2.2倍和5.2倍.
- 更新后的14项PERS表现出比以前的模型更好的性能.
结论:
- 儿童和青少年风险因素的综合评分预测了青春晚期精神病症状.
- 风险因素的累积影响对于理解精神病理发展至关重要.
- 未来的研究应该在心理病理学研究中纳入累积风险评估.
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