相关实验视频
Updated: May 7, 2026

12:24
Murine Model of CD40-activation of B cells
Published on: March 6, 2010
针对淋巴瘤治疗的CD30的进展:历史视角和未来方向
Hongju Zhang1,2, Yuting Yan1,3, Shuhua Yi1,3
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Expert review of hematology
|April 14, 2025
概括
CD30是淋巴瘤治疗的一个关键点. 布伦图西马布维多丁显示有效性,但耐药性需要新的治疗方法,如CAR-T细胞和双特异性抗体,以改善患者管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- CD30是一种在活性淋巴细胞和淋巴状瘤上发现的跨膜蛋白.
- 它在各种淋巴瘤中起着至关重要的作用,包括霍奇金淋巴瘤和非霍奇金淋巴瘤.
研究的目的:
- 审查CD30作为淋巴瘤治疗标和预后指标的重要性.
- 提供对抗CD30疗法和未来研究方向的全面概述.
主要方法:
- 从1987年到2024年使用PubMed,Scopus和Web of Science进行了广泛的文献搜索.
- 对CD30表达,治疗干预和临床结果的研究分析.
主要成果:
- 布伦图西马布维多丁 (BV) 已推进了CD30+淋巴瘤治疗,显示出有效性和可管理的安全性.
- 对BV的耐药性对一些患者来说是一个挑战.
- 如CAR T细胞和针对CD30的双特异性抗体等创新疗法正在开发中.
结论:
- CD30是淋巴瘤诊断,预后和治疗策略的关键标志物.
- 目前正在进行的研究重点是克服耐药性和开发新的CD30向疗法.
- 这些进展旨在改善CD30+淋巴瘤患者的治疗和治疗结果.
相关概念视频
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Tumor Immunotherapy
404
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
404

