莫琳达叶L:关于植物化学,药物效应和抗氧化潜力的综合性审查
Silu Hou1,2,3, Danyang Ma1,2,3, Shaofeng Wu1,2,3
1Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya 572025, China.
Antioxidants (Basel, Switzerland)
|April 14, 2025
概括
尼尼 (Morinda citrifolia) 通过清除自由基和增强自然防御,表现出强大的抗氧化特性. 它的化合物显示出医疗和制药创新的希望,特别是在营养保健品中.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 莫琳达叶 (Morinda citrifolia L. (noni) 是一种传统的波利尼西亚药用植物,具有很长的使用历史.
- 诺尼因其丰富的抗氧化植物化学物质而闻名,包括黄类,类,多糖类和类.
研究的目的:
- 审查最近 (2018-2023) 关于 noni 的生物活性成分,药理性质和分子机制的进展.
- 专注于诺尼的抗氧化潜力及其潜在机制.
主要方法:
- 对 noni 衍生化合物的系统分析.
- 评估自由基清除能力 (DPPH/ABTS抑制).
- 对抗氧化酶 (SOD,CAT,GPx) 和信号通路 (Nrf2/Keap1,NF-κB) 的调制进行评估.
主要成果:
- 非化合物表现出显著的自由基清除活性.
- 无成分可提高内源抗氧化酶的调节,并调节关键的抗氧化途径.
- 多糖和化物通过肠道微生物群的调节表现出双重抗氧化和抗炎作用.
结论:
- 诺尼是一种多目标抗氧化剂,具有医学和制药创新的潜力,特别是在营养药和牲畜料中.
- 需要进一步的研究来阐明作用机制,并确保更广泛的应用的安全性.
- 机械学研究对于将传统知识与 noni 的现代应用联系起来至关重要.
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