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临床病理学和分子特征非小细胞肺癌与心周溢血

Weijie Ma¹, Nathalie J Rodrigues Simoes¹, Peter P Seery¹

¹Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

Cancer cytopathology

|April 14, 2025

概括

在非小细胞肺癌 (NSCLC) 中对心周溢液 (PE) 的细胞学评估至关重要. 负细胞学预测了更好的生存率,突出显示了NSCLC患者具有PEs的综合诊断方法的重要性.

科学领域:

在瘤学瘤学.
病理学病理学病理学
细胞病理学细胞病理学

背景情况:

心周溢液 (PE) 是非小细胞肺癌 (NSCLC) 的重要并发症.
对PEs的细胞学评估对于NSCLC患者的诊断和预后至关重要.
这项研究回顾性地分析了患有PEs的NSCLC患者的临床病理学,分子和预后因素.

研究的目的:

评估细胞学评估和国际血清流体细胞病理报告系统 (ISRSFC) 分类在NSCLC相关的PEs中的作用.
研究患有PEs的NSCLC患者的临床病理学,分子和生存特征.
确定PEs中细胞学发现对NSCLC的预后意义.

主要方法:

15年来对80名患有PEs的NSCLC患者的临床数据进行了回顾性审查.
使用ISRSFC对PE标本进行分类.
对患者人口统计,分子变化 (p53,KRAS,EGFR),细胞病理学,组织学和生存结果的分析.

主要成果:

45%为女性,90%为IV期NSCLC;27.5%呈现出吸管.
在ISRSFC分类:63.75%恶性 (MAL),25%恶性阴性 (NFM).
在NFM患者中,生存率显著提高 (p=0.0036);在IV期患者中,免疫疗法改善了生存率.

结论:

细胞学评估和ISRSFC分类对于管理NSCLC相关的PEs至关重要.
结合细胞学,免疫组织化学和分子分析的多学科方法至关重要.
细胞学阴性状态是一个独立的预后因素,用于改善PEs的NSCLC患者的存活率.

关键词:

国际血清液细胞病理报告系统 (ISRSFC)生物标志物生物标志物分子特征的分子表征.不是小细胞肺癌的肺癌心脏周围排泄物心脏周围排泄物预后预后预后

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