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Samuel Adida^1,2, Suchet Taori^1,2, Zayaan Tirmizi¹

¹School of Medicine, University of Pittsburgh Medical Center, 3550 Terrace St, Pittsburgh, PA, 15213, USA.

Journal of neuro-oncology

|April 14, 2025

概括

立体体辐射疗法 (SBRT) 提供有效的局部控制和缓解胃肠癌脊髓转移的疼痛. 这种治疗表明毒性最小,失败率和不良事件率低.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
胃肠道瘤学胃肠道瘤学

背景情况:

胃肠道 (GI) 癌症转移到脊椎通常是抗辐射的.
癌症治疗的进步导致了生存率的提高和脊髓转移的更高发病率.

研究的目的:

评估从胃肠道癌引起的脊髓转移的立体体辐射疗法 (SBRT) 的结果.
通过对SBRT用于肠道癌脊髓转移的综合文献审查来补充发现.

主要方法:

对75名患有106例胃肠道癌脊髓转移的患者的前性维护数据库的分析. 用SBRT治疗.
给药剂量范围从单个分数中的14-16 Gy到2-5个分数中的18-35 Gy.

主要成果:

较低的12个月局部衰竭率 (6-13%取决于原发性胃肠道癌部位).
在88%患有疼痛瘤的患者中观察到显著的疼痛缓解.
脊椎压缩骨折率低 (9%) 和辐射毒性 (11%),没有神经病变或骨髓病变的病例.

结论:

SBRT是肠道癌脊髓转移的有效治疗方法,提供良好的局部瘤控制和疼痛缓解.
该治疗与最小的毒性有关,使其成为患者的可行选择.
预计胃肠道癌脊髓转移的发生率将增加,这凸显了有效的SBRT策略的重要性.

关键词:

胃肠道胃肠道胃肠道放射性外科手术放射性外科脊柱立体性身体辐射疗法脊椎转移的发生.刻板印象性的身体辐射疗法对瘤进行控制.

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