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患有IBD和癌症史的患者的管理
Ilaria Faggiani1, Sarah Bencardino1, Mariangela Allocca1
1Department of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
先进的疗法越来越多地用于炎症性肠病 (IBD),即使在有癌症病史的患者中也是如此. 现实世界的数据支持它们的安全使用,以风险分层和多学科护理为指导.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 像生物药物和小分子这样的先进疗法是适度至严重的性结肠炎 (UC) 和克罗恩病 (CD) 的标准.
- 患有癌症史的患者通常被排除在临床试验之外,从而限制了其治疗的证据.
- 这种排除在高风险人群中管理炎症性肠病 (IBD) 的临床医生面临挑战.
研究的目的:
- 审查关于在IBD患者中使用先进治疗的现有证据,这些患者有癌症史.
- 为了解决知识差距,并提供实际的管理见解.
- 为这个特定的患者群体支持基于证据的决策.
主要方法:
- 对现实世界的数据和更新的指导方针进行了全面的文献审查.
- 分析风险分层策略和多学科护理模式.
- 评估先前恶性瘤患者先进治疗的安全性和有效性数据.
主要成果:
- 新出现的现实数据和最新的指导方针表明,在IBD患者中安全使用先进疗法,这些患者先前有恶性瘤.
- 风险分层和瘤学家的投入对于优化结果至关重要.
- 多学科方法对于平衡IBD活动和癌症复发风险至关重要.
结论:
- 对于有癌症史的IBD患者,可以考虑先进疗法.
- 谨慎的患者选择,风险评估和多学科团队是至关重要的.
- 需要进一步的研究来填补现有的知识空白在这个领域.
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