超越遗传学:探索口腔癌发展中的生活方式,微生物组和社会决定因素
Anil Menon1, Vimi S Mutalik2, Yongqiang Chen3
1Department of Preventive Dental Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.
Cancers
|April 14, 2025
概括
本综述探讨了生活方式,口腔微生物组和社会经济因素如何相互作用,影响口腔癌的进展. 了解这些综合效应对于制定更好的预防和治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 微生物学 微生物学
背景情况:
- 口腔癌是一个重要的全球健康问题,排名第16最常见的癌症和癌症死亡率的第六大原因.
- 目前对口腔癌进展机制和早期诊断干预措施的理解需要改进.
- 现有的审查往往侧重于单个风险因素,忽视它们对口腔癌的综合影响.
研究的目的:
- 审查生活习惯,口腔微生物组和社会经济因素对口腔癌进展的综合影响.
- 在口腔癌的背景下突出这些细胞外因素之间的相互作用.
- 为研究人员提供有关影响口腔癌的因素的最新概述.
主要方法:
- 文献综述综合了口腔癌现有研究.
- 集中分析生活方式,口腔微生物组和社会经济地位的相互作用.
- 评估这些因素如何单独和集体影响口腔癌的发展和进展.
主要成果:
- 生活方式因素,如饮食 (高糖,加工食品,酒精,吸烟) 促进口腔癌,而其他因素 (水果,蔬菜,茶,咖啡,运动) 可能会对抗它.
- 口腔微生物组可以抑制或促进口腔癌的进展.
- 低社会经济地位与口腔癌风险增加有关,这些因素之间的相互作用显著影响结果.
结论:
- 生活方式,口腔微生物组和社会经济地位的联合影响对口腔癌的进展至关重要.
- 进一步的研究应优先研究这些多因素相互作用,以改善口腔癌的预防和治疗.
- 本次审查强调了需要采用综合方法来解决这些相互关联的因素.
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