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在患有缺血性中风或脑内出血的年轻成年人中,发生中风后的风险

Esmée Verburgt¹, Lina Fellah¹, Merel S Ekker¹

¹Department of Neurology, Radboud Institute of Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands.

|April 14, 2025

概括

在年轻人中,中风后 (PSE) 的风险很低,皮质干扰和早期是关键预测因素. 现有的风险评分,如SELECT 2.0和CAVE对于这个年龄组是有效的.

科学领域:

神经学神经学
发病学 (Epileptology) 是一个专业的学科.
脑卒中医学脑卒中医学

背景情况:

脑卒中后 (PSE) 是年轻人的严重并发症,影响功能恢复.
现有的PSE风险预测得分在年轻的中风人群中缺乏验证.

研究的目的:

确定年轻成年人PSE的风险和识别风险因素.
在这个人口群体中验证现有的PSE风险评分 (SeLECT 2.0和CAVE).

主要方法:

一项前性队列研究 (ODYSSEY) 对1388名年轻成年人 (18-49岁) 进行了神经成像证明的中风.
分析包括5年PSE风险的累积发病率函数和风险因素的细灰回归.
使用C统计和校准图表验证SELECT 2.0和CAVE分数的验证.

主要成果:

在缺血性中风后,5年累计PSE风险为3.7%,在脑内出血 (ICH) 后为7.6%.
PSE的主要风险因素包括急性症状性和缺血性中风的皮质参与,以及ICH的皮质参与.
无论是SELECT 2.0还是CAVE风险评分都显示了年轻成年人的良好表现和校准.

结论:

年轻成年人患PSE的风险相对较低.
目前的PSE风险评分适用于年轻人,有助于风险分层.
需要进一步的研究来确定高风险个体的最佳预防策略.

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