具有EFGR突变,KRAS突变或没有突变的肺腺癌的整体生存趋势
Martin Faehling1, Sabine Fallscheer1, Birgit Schwenk1
1Clinic of Cardiology and Pneumology, Esslingen Hospital, 73730 Esslingen, Germany.
Cancers
|April 14, 2025
概括
现实数据显示,现代肺腺癌治疗方法,包括检查点抑制剂 (CPI) 和奥西默提尼布,与旧方法相比,显著改善整体存活率 (OS). 克拉斯患者从CPI中受益,类似于没有突变的患者.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床实践 临床实践
背景情况:
- 肺腺癌治疗已经发展成为针对EGFR突变和检查点抑制剂 (CPI) 的向疗法,如奥西默蒂尼布.
- 有限的现实数据存在,比较当前和历史患者子组之间的长期整体存活率 (OS).
研究的目的:
- 为了比较IV期肺腺癌患者在不同突变状态 (EGFR,KRAS,无突变) 和治疗时代的实际整体存活率 (OS).
- 评估现代疗法 (CPI, osimertinib) 对肺腺癌的生存系统的影响.
主要方法:
- 在KOMPASS研究中,分析了第四阶段肺腺癌患者的现实数据.
- 根据突变测试和诊断日期,患者被分为"当前" (NGS测试,诊断2021) 和"历史" (仅EGFR PCR,诊断2014) 队列.
- 队列包括EGFR突变,KRAS突变和没有突变的组.
主要成果:
- 当前和历史的EGFR突变队列都比各自的无突变组显著长的OS.
- 目前没有突变和EGFR突变的队列比历史队列更长的OS趋势.
- 无突变队列的OS改善与更多的长期幸存者有关,而EGFR队列的中位数OS有所改善,但长期幸存者的数量没有显著增加.
- KRAS突变患者的生存状况与无突变患者相似,长期存活率约为20%.
结论:
- 现实世界的结果与III期试验 (KEYNOTE-189,FLAURA) 相一致,表明CPI和 osimertinib的成功转化为临床实践.
- 现代治疗显著改善了肺腺癌中的OS,与临床试验结果相比.
- 患有KRAS突变肺腺癌的患者从CPI治疗中获得的OS益处与没有突变的患者相似.
关键词:
欧洲粮食和农作物管理委员会 (EFGR) 提供.在Exon 21中,Exon 21是第21个.在G12D中,G12D是指G12D.克拉斯 (Kras) 是一个国家.检查点抑制剂检查点抑制剂肺癌是一种肺癌.总体存活率 总体存活率现实世界的数据数据.更多相关视频
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