通过肠道微生物组调节优化癌症治疗
Kyuri Kim1, Mingyu Lee2, Yoojin Shin2
1College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul 03760, Republic of Korea.
Cancers
|April 14, 2025
概括
肠道微生物组显著影响癌症治疗的有效性,影响免疫疗法和化疗的结果. 个性化微生物组策略显示出优化癌症治疗的前景.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群影响癌症治疗效率和患者的治疗结果.
- 微生物失生症与不良反应和治疗耐药性有关.
研究的目的:
- 探索肠道微生物组在调节癌症治疗中的作用.
- 突出基于微生物组的战略,以提高治疗疗效和降低毒性.
主要方法:
- 对微生物组与癌症治疗相互作用的新兴证据的审查.
- 微生物种类,代谢物和工程微生物系统的分析.
主要成果:
- 特定的微生物增强免疫检查点抑制剂的有效性.
- 微生物组的组成会影响化疗的有效性.
- 微生物代谢物和工程益生菌/益生菌显示治疗潜力.
结论:
- 肠道微生物组是癌症治疗反应的关键因素.
- 个性化,基于微生物组的方法对于优化癌症治疗至关重要.
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