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同时服用精神兴奋剂是否会减轻第二代抗精神病药物相关的体重增加? 一项基于电子医疗记录数据的观察研究
Ning Lyu1, Paul J Rowan2, Tyler J Varisco1
1College of Pharmacy, University of Houston, Houston, Texas, USA.
Journal of child and adolescent psychopharmacology
|April 14, 2025
概括
精神兴奋剂可能有助于减少服用第二代抗精神病药物 (SGA) 的儿童和青少年的体重增加. 这项研究发现,同时使用精神兴奋剂或稍后添加它们可以减轻与SGA相关的体重增加.
科学领域:
- 儿科精神病学 儿科精神病学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 体重增加是第二代抗精神病药物 (SGA) 的常见副作用.
- 精神兴奋剂在儿科患者群体中经常与SGA一起处方.
- 精神兴奋剂对SGA相关体重增加的影响需要调查.
研究的目的:
- 为了确定精神兴奋剂是否减轻使用SGA的儿科患者的体重增加.
- 为了比较儿童和青少年的体重变化,使用SGA与或没有同时使用/添加精神兴奋剂.
主要方法:
- 使用IQVIA的回顾性队列研究 门诊电子医疗记录-美国数据库 (2016-2021).
- 确定的儿科患者 (6-17岁) 开始SGA,分为SGA-only,同时使用精神兴奋剂和附加精神兴奋剂的用户.
- 倾向性得分调整和线性混合效应回归模型分析了6个月和12个月的BMIz-score趋势.
主要成果:
- 同时使用精神兴奋剂的使用者在6个月内,与仅使用SGA的用户相比,每月BMIz-score的增加明显较低.
- 加上精神兴奋剂的使用者也表现出明显较低的体重增加率,而不是仅使用SGA的用户.
- 12个月后的敏感性分析证实了这些发现.
结论:
- 同时和添加精神兴奋剂的使用似乎可以减轻SGA相关的儿童患者的体重增加.
- 需要进一步的研究来评估精神兴奋剂在管理抗精神病药物诱导的体重增加方面的比较有效性和安全性.
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