法国多发性硬化症发病率更新,2011-2021年
Octave Guinebretiere1, Chloe Pierret2, Quentin Calonge3,4,5
1Sorbonne Université, Paris Brain Institute - ICM, Inserm, CNRS, Inria, France.
Neurology
|April 14, 2025
概括
在2011-2021年期间,法国的多发性硬化症 (MS) 发病率保持稳定. 然而,多发性硬化症的患病率有所增加,这表明患者的生存率和管理水平更好,需要持续的医疗保健支持.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是年轻人神经障碍的主要原因.
- 全球MS患病率正在上升,但最近的发病率趋势需要澄清.
- 法国庞大的国家健康数据库为研究多发性硬化症流行病学提供了独特的机会.
研究的目的:
- 评估法国MS发病率的最新时间趋势.
- 为了分析MS发病率,使用来自全国卫生登记处的11年数据集.
- 为欧洲主要人口提供有关多发性硬化症流行病学的见解.
主要方法:
- 利用经过验证的算法来识别2011-2021年间发生的MS病例.
- 采用特定和敏感案例定义来进行可靠的发病率估计.
- 应用多变量波桑回归来分析时间发病率趋势和性别/年龄标准化.
主要成果:
- 通过使用特定的定义,确定了超过5万例发生性多发性硬化病例.
- 在11年研究期间发现稳定的MS发病率 (IRR 0.998).
- 观察到女性与男性的比例稳定,但MS患病率上升,表明生存率有所改善.
结论:
- 在法国,MS发病率和性别比率保持稳定.
- 增加多发性硬化症的患病率突出显示了改善的患者管理和生存率.
- 医疗保健系统必须适应,以支持不断增长的MS人口.
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