阻塞性睡眠呼吸暂停风险与过敏性喘的关联:系统性审查和元分析
1Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Medicine
|April 14, 2025
概括
过敏性喘患者有明显更高的阻塞性睡眠呼吸暂停 (OSA) 的患病率和风险. 这一元分析证实了这些疾病之间存在着密切的联系.
科学领域:
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 喘和阻塞性睡眠呼吸暂停 (OSA) 分享重叠的病理生理机制.
- 喘和过敏性喘之间的特殊关系需要进行系统的调查.
研究的目的:
- 在过敏性喘患者中系统地审查和元分析阻塞性睡眠呼吸暂停 (OSA) 的患病率和风险.
主要方法:
- 在主要的科学数据库中进行了全面的文献搜索.
- 关键词包括"过敏性喘"和"阻塞性睡眠呼吸暂停" (OSA).
- 统计分析涉及计算危险比率,赔率比率 (OR) 和风险比率,使用固定和曼特尔-汉泽尔方法在 Stata.
主要成果:
- 包括19篇文章,分析了过敏喘患者OSA的患病率和风险.
- 在过敏性喘患者中,OSA的患病率为35.25% (95% CI:19.92%50.57%),几率显著增加 (OR = 2.24,P < 0.001).
- 过敏性喘患者的OSA风险为30.08% (95%CI:19.73%40.43%),其几率显著增加 (OR = 3.46,P < 0.001).
结论:
- 患有过敏性喘的患者表现出阻塞性睡眠呼吸暂停 (OSA) 的患病率明显较高.
- 在过敏性喘患者中,患上OSA的风险显著增加.
- 这些发现强调了在喘管理中考虑OSA的重要性.
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