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大脑微RNA在与年龄相关的大脑病理中差异表达.

Tianze Luo1, Selina M Vattathil2, Adriana Lori3

  • 1Department of Neurology, Emory University, Atlanta, GA, USA.

Neurobiology of aging
|April 14, 2025
PubMed
概括

微RNAs (miRNAs) 在阿尔茨海默氏症等与年龄相关的脑疾病中发挥作用. 这项研究确定了与各种病理相关的特定miRNA,提供了对其生物基础的见解.

关键词:
与年龄相关的大脑病理.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.动脉样硬化是动脉样硬化的一种.大脑的微RNA.大脑粉样性血管病变 - 大脑粉样性血管病变在LATE-NC时代.列维体病理学 列维体病理学

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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