在痴呆症的养老院居民中,COVID-19与药物变化相关的因素
Alison C Rataj1, Kate L Lapane1, Brian R Ott2
1University of Massachusetts Chan Medical School, Worcester, MA, USA.
概括
高COVID-19死亡率的养老院减少了抗痴呆药物的使用. 疫情期间居民行为问题增加与更多的精神药物药物启动有关.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19大流行严重影响了养老院 (NH) 运营和居民护理.
- 在此期间,观察到药物实践的变化,包括抗痴呆症和精神药物.
- 了解这些变化对于在公共卫生危机期间管理痴呆症护理至关重要.
研究的目的:
- 调查COVID-19死亡率,人员配置和居民行为与痴呆症老人院居民药物开始之间的关系.
- 分析疫情的高峰如何影响抗痴呆症和精神药物的处方.
- 在COVID-19公共卫生紧急情况期间,确定与药物启动变化相关的因素.
主要方法:
- 对全国代表性的护理主任调查的分析.
- 在流行病的高峰期对抗痴呆症和精神药物药物启动的变化的评估.
- 统计检查COVID-19死亡率,人员配置,居民行为和药物开始之间的关联.
主要成果:
- 在COVID-19死亡率较高的养老院中,抗痴呆药物的开始减少.
- COVID-19死亡率与精神药物治疗开始的变化没有显著的相关性.
- 增加居民行为问题与更高的精神药物药物启动几率有关.
结论:
- 受COVID-19死亡严重影响的养老院不太可能增加抗痴呆症药物治疗的开始.
- 增加的精神药物使用与增加的行为症状有关,可能会被COVID-19加剧.
- 需要进一步的研究,以了解公共卫生紧急情况期间的处方做法.
更多相关视频
12:18A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
7.4K
04:13Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
Published on: February 8, 2019
6.7K
相关概念视频
Dementia
73
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
73
Factors Affecting Drug Response: Overview
1.7K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.7K
Factors Affecting Drug Distribution: Miscellaneous Factors
192
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
192
Drug Therapy
30
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
30
Factors Affecting Protein-Drug Binding: Patient-Related Factors
31
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
31
Alzheimer's Disease: Treatment
128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128
