使用化学发光试验的尿皮质醇与肌素比率对犬类高皮质醇症的诊断准确性有限
Francesca Del Baldo1, Alessandro Tirolo2, Francesco Dondi1
1Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
American journal of veterinary research
|April 14, 2025
概括
这项研究确定了健康狗尿皮质醇与肌素比率 (UCCR) 的新参考间隔. UCCR显示高皮质醇症 (HC) 的诊断性能适度,不应单独用于诊断.
科学领域:
- 兽医内科 兽医内科
- 临床病理学 临床病理学
- 内分泌学 在内分泌学.
背景情况:
- 高皮质醇症 (HC) 是狗常见的内分泌疾病.
- 准确的诊断测试对于及时诊断和治疗至关重要.
- 建立可靠的参考间隔 (RIs) 对于解释诊断测试结果至关重要.
研究的目的:
- 在健康的狗 (HDs) 中建立尿皮质醇与肌素比率 (UCCR) 的 de novo参考间隔 (RI).
- 评估高皮质醇症 (HC) 狗中UCCR的诊断性能.
- 评估UCCR在区分HC与模仿HC的疾病 (DMHC) 中的实用性.
主要方法:
- 追溯和前性观察性研究设计.
- 包括172只狗:97只HC,35只DMHC和40只HD.
- 使用接收器操作特征 (ROC) 曲线评估UCCR诊断性能.
主要成果:
- 在3 X 10-6和26 X 10-6之间建立了HD中UCCR的de novoRI.
- 在HC的狗中,与DMHC和HD相比,中位数UCCR显著更高.
- ROC分析给出了0.85的曲线下的面积,用于区分HC与DMHC.
结论:
- 在UCCR中,HC的诊断性能很低,在确定的截止值时灵敏度为80.4%,特异性为71.4%.
- 单独的UCCR不足以排除狗中的HC.
- 当临床怀疑HC时,建议进行进一步的内分泌检测.
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