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低调格兰酶M表达:对免疫系统的影响和甲状腺癌的预后

Jingying Pan¹, Bidong Fu², Shuhan Huang²

¹Department of Ultrasonography, Second Affiliated Hospital of Nanchang University, Nanchang, China; First College of Clinical Medicine, Nanchang University, China.

|April 14, 2025

概括

格兰酶家族成员GZMM在甲状腺癌 (THCA) 中降低调节,抑制瘤进展,并与预后不佳有关. 低GZMM表达可能作为THCA的诊断和预后因素.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

甲状腺癌 (THCA) 是全球最常见的内分泌癌症,发病率越来越高.
大酶家族成员GZMM在瘤细胞炎症和亡中起作用.
在THCA中GZMM的特定作用仍然在很大程度上未被探索.

研究的目的:

研究甲状腺癌中GZMM的表达,功能和预后意义.
探索GZMM与THCA中的瘤免疫微环境之间的关系.
开发基于GZMM和表观遗传修饰的THCA风险预测模型.

主要方法:

使用TCGA和TIMER数据库进行生物信息学分析.
在体外功能测试以评估GZMM对血管生成,侵袭和迁移的影响.
单变量和多变量考克斯回归和ROC曲线分析用于预后评估.

主要成果:

在THCA组织中,GZMM蛋白水平显著下调,并与临床病理特征相关.
低GZMM表达与THCA患者的整体生存率差相关,表明预后价值.
GZMM抑制了瘤的侵袭,迁移和血管生成,并增强了CD8+ T细胞的透.

结论:

在THCA中,GZMM通过抑制侵袭,迁移和血管生成,起到瘤抑制作用.
GZMM表达是THCA的显著预后生物标志物,并影响瘤免疫微环境.
结合GZMM和表观遗传修饰的新型风险预测模型可能有助于THCA管理.

关键词:

血管新生的产生.生物标志物生物标志物表观遗传改变表观遗传改变 GZMM GZMM 在线观看免疫系统的透.甲状腺癌是一种甲状腺癌.

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