桃体微生物群的变化通过歪曲老年中性粒细胞,有助于牛皮的免疫反应
Jiaoling Chen1, Xuan Liu1, Yaxing Bai1
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
The British journal of dermatology
|April 14, 2025
概括
在牛皮患者中,改变的桃体微生物群和减少的短链脂肪酸 (SCFA) 通过影响免疫细胞功能,导致皮肤炎症. 这些发现表明牛皮的新治疗点.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 微生物群和免疫媒介疾病之间的联系正在出现.
- 桃体微生物群在皮肤炎症 (如牛皮) 中的特定作用尚不清楚.
研究的目的:
- 为了研究桃体微生物群对牛皮的影响.
- 阐明将桃体微生物与皮肤炎症联系起来的分子机制.
主要方法:
- 在28名牛皮患者和24名对照人群中比较了桃体微生物组成,使用16S rRNA和元基因组测序.
- 在患者和对照组中测量了血清短链脂肪酸 (SCFA).
- 在实验室中评估了SCFA对中性粒细胞功能的影响.
主要成果:
- 牛皮患者的桃体微生物多样性发生了变化,Bacteroidales增加,Burkholderiales,Micrococcales和Pasteurellales减少.
- 减少Rothia mucilaginosa与较低的系统性炎症和牛皮的严重程度相关.
- 在牛皮患者中观察到较低的血清SCFAs水平,这与破坏的代谢途径有关.
- 这种SCFA抑制了中性粒细胞的衰老,促炎性细胞因子的释放和中性粒细胞外细胞陷 (NET) 的形成.
结论:
- 桃体微生物群及其代谢物的变化有助于牛皮病原.
- 桃体微生物和SCFA对免疫反应的调节对银病治疗有潜在的临床影响.
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