灵长类动物腹筋体内的功能异质性,用于激励调节
Haruhiko Iwaoki1, Yukiko Hori1, Yuki Hori1
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
概括
前腹条纹体 (VS) 导致休息,而后面的VS在灵长类动物中触发了强迫性检查. 这揭示了VS子区域在动机和精神疾病中的独特功能.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物的行为
- 神经药理学神经药理学
背景情况:
- 腹状条纹体 (VS) 对于奖励和动机至关重要.
- 它在灵长类动物中的功能划分尚未得到充分理解.
- VS功能障碍与冷漠和强迫症有关.
研究的目的:
- 调查灵长类VS.中的功能异质性.
- 区分前部 (aVS) 和后部 (pVS) VS 的作用.
- 探索VS参与的动机控制回路.
主要方法:
- 使用muscimol. 在子中双边药理性VS无活化.
- 通过CT和MRI扫描进行精确的准.
- 使用目标定向的任务和自发的行为观察进行行为分析.
主要成果:
- 前部VS无活化导致低活性 ("休息").
- 后面的VS无活化导致了强迫性"检查"行为.
- 两种失活都没有影响奖励价值或驱动力,使它们与其他激励领域区别开来.
结论:
- 灵长类人VS在前后轴上表现出功能异质性.
- aVS和pVS都涉及到不同的动机控制电路.
- 研究结果提供了对精神疾病和潜在治疗方法的见解.
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