生物能量生物标志物作为预测指标及其与新诊断的双相情感障碍患者的认知功能之间的关系,这些患者从未使用过药物
Ting Cao1,2, BaoYan Xu2,3,4, SuJuan Li2,3
1Department of Pharmacy, Institute of Clinical Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Translational psychiatry
|April 14, 2025
概括
双相情感障碍 (BD) 的能量产生变化与认知问题有关. 这项研究发现,血液中的特定三碳酸 (TCA) 循环代谢物可以帮助诊断BD并了解其认知影响.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 精神病学是一个精神病学.
背景情况:
- 线粒体功能障碍和生物能学障碍与双相情感障碍 (BD) 病变发生有关.
- 认知障碍是BD的一个关键症状,可能与线粒体异常有关.
- 三碳酸 (TCA) 循环在BD相关认知功能障碍中的作用尚不清楚.
研究的目的:
- 为了研究血清TCA循环代谢物与第一个插曲,未使用药物的BD患者的认知功能之间的关联.
- 确定BD的潜在生物标志物,并了解它们与线粒体功能障碍和认知障碍的联系.
主要方法:
- 对144名BD患者和51名健康对照进行了横截面研究.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 量化血清TCA循环代谢物.
- 使用可重复电池评估神经心理状态 (RBANS) 和Stroop色词测试来评估认知功能.
主要成果:
- 与对照组相比,BD患者的血清TCA代谢物水平显著提高,认知得分较低.
- 在BD患者中,特定代谢物与焦虑正相关,与认知表现负相关.
- 酸,α-甲酸 (α-KG) 和酸被确定为BD的独立风险因素,具有诊断效用.
结论:
- 血清生物能代谢物,特别是酸,α-KG和酸,显示出早期BD诊断的生物标志物的潜力.
- 这些发现提供了关于线粒体功能障碍的见解,这些功能障碍是BD的潜在认知缺陷.
- 这项研究支持开发针对BD的有针对性的治疗策略.
更多相关视频
10:28Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
15.0K
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.5K
相关概念视频
01:30Bipolar Disorder
37
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
37
01:24Mania and Antimanic Drugs: Overview
103
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
103
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
38
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
38