大脑活动,与托相关的肠道代谢物和自闭症症状学之间的关系
Lisa Aziz-Zadeh1,2, Sofronia M Ringold3,4, Aditya Jayashankar3,4
1Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA. lazizzad@usc.edu.
Nature communications
|April 14, 2025
概括
肠道微生物托芬代谢物的较低水平,如金酸盐,与儿童自闭症谱系障碍 (ASD) 脑活动和症状严重程度有关. 这表明肠道健康和ASD病理生理学之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 肠道微生物代谢物的变化被假设为自闭症谱系障碍 (ASD) 病理生理学的贡献.
- 肠道微生物代谢物与ASD特异性脑部变化之间的关系尚不清楚.
研究的目的:
- 研究肠道微生物代谢物与ASD儿童大脑活动之间的关联.
- 探索特定微生物代谢物,大脑功能和ASD症状严重程度之间的联系.
主要方法:
- 这是一项横截面的病例对照观察研究,涉及43名患有自闭症儿童和41名神经类型 (NT) 儿童 (8-17岁).
- 利用便代谢学,基于任务的功能磁共振成像 (fMRI) 与社会情感和感官范式,以及行为评估.
- 分析了便代谢物,fMRI衍生的脑活动 (岛屿和带膜皮质) 和ASD症状措施 (例如ADOS分数) 之间的关联.
主要成果:
- 与NT儿童相比,在患有ASD的儿童中观察到酸相关代谢物的便水平显著降低,包括金酸.
- 这些代谢物水平与岛内皮层和带带皮层的活性变化相关,这些大脑区域与ASD有关.
- 中岛和中环活动调解了特定微生物酸代谢物 (酸,酸和贝他因) 与ASD严重程度,厌恶敏感性和感官敏感性之间的关系.
结论:
- 确定了肠道微生物托代谢产物,ASD症状和儿童的大脑活动之间的显著关联.
- 这些发现突显了肠道微生物代谢物在自闭症病理生理学中的作用,特别是关于大脑中的感觉处理区域.
- 表明肠道微生物组衍生型酸盐代谢与ASD中观察到的神经生物学差异之间存在潜在的联系.
相关概念视频
01:19Autism Spectrum Disorder
38
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
38
01:17Irritable Bowel Syndrome I: Introduction
207
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
207
01:31Neurotransmitters
728
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
728
01:26Modeling in Therapy
33
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
33