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Updated: May 13, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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β-上腺素受体通过降低Yap m6A修饰的调节来抑制心脏再生

Kaihang Guan1, Zijian Li2,3

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.

Cell death & disease
|April 14, 2025
PubMed
概括

贝塔-上腺素受体 (β-AR) 通过减少Yap m6A修饰来抑制哺乳动物的心脏再生. 这项研究揭示了亚型特定的机制,为心脏修复提供了新的治疗策略.

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