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Updated: May 13, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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H3.1K27M诱导的TONSOKU-H3.1通路的错误调节导致基因组不稳定

Wenxin Yuan1, Yi-Chun Huang1, Chantal LeBlanc1

  • 1Department of Molecular, Cellular and Developmental Biology, Faculty of Arts and Sciences, Yale University, New Haven, CT, USA.

Nature communications
|April 14, 2025
PubMed
概括

在植物中,H3K27M基因会破坏染色质的成熟,导致DNA损伤和基因组不稳定. 这将基因组突变与癌症状的变化联系起来,并建议扩散中线质瘤的新治疗点.

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